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Mechanistic studies indicate that TMAO can stimulate hepatocytes to release exosomes that are taken up by vascular endothelial cells, inducing expression of inflammatory cytokines (including IL-6, MCP-1, and TNF-), activating NF-B signaling, increasing endothelial cell apoptosis, and impairing endothelium-dependent vasodilation [116]
Your Weight Loss Doctor License ME130218 Donald Donny Paul Thometz has diverse professional experience including working in emergency departments both in the US and internationally, where he further honed his skills in acute care medicine
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[DOI] [PMC free article] [PubMed] [Google Scholar] Baez S, Segura-Aguilar J, Widersten M, Johansson AS and Mannervik B
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