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Potential Research Observations: Enhanced anabolic signaling and protein synthesis in target tissues [1]

In particular, non-exempted class I (low risk) and class II (moderate risk) devices for which a predicate device exists can rely on the 510(k) premarket notification pathwayresulting in a medical device clearance to marketinstead of the significantly more onerous Premarket Approval (PMA) application pathway used primarily for Class III (high risk) devices

J Clin Endocrinol Metab 96:853860 [DOI] [PubMed] [Google Scholar] 44.Mabilleau G, Mieczkowska A, Irwin N, Flatt PR, Chappard D (2013) Optimal bone mechanical and material properties require a functional glucagon-like peptide-1 receptor