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Insulin Independent Pathways for Glucose Disposal GLP-1: Increase in GLUT4 expression by activating AMPK LeuSynergy: Increase in GLUT4 expression through SIRT1 deacetylation of PGC-1a Improved Fat Oxidation GLP-1: Direct effects on hepatocytes by activating genes involved in beta-oxidation of fatty acids LeuSynergy: Activation of PGC-1a and PPAR resulting in an increase in fatty acid oxidation and oxidative phosphorylation Oxidative Stress and Pancreatic Beta Cell Protection GLP-1: Reduced oxidative stress in pancreatic islets

GISSI-HF investigators

Commonly prescribed or recommended dietary supplements include coenzyme Q 10 and vitamin B, C, E and K [9,10]

A bariatric surgeon will assess candidacy based on clinical criteria, not just BMI