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Vitamin B12 deficiency may cause numbness and tingling in the hands and feet, cognitive impairment, and reduced neurotransmitter production in the brain and spinal cord

The review confirmed that in vitro, 5-Amino-1MQ significantly reduced intracellular 1-MNA, increased intracellular NAD+, and suppressed lipogenesis in adipocytes

Of course, people with a proper vitamin B12 deficiency will see more of a benefit, like improvement with less fatigue, nausea, and irritability