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c-KIT-mediated ERK signaling pathway can induces CREB phosphorylation to activate melanin synthesis on one hand, and on the other hand, the activation of ERK signaling has been demonstrated to phosphorylate MITF at the serine 73 residue, which leads to the ubiquitination and degradation of MITF, this is the feedback mechanism of the ERK pathway to regulate melanin production (3,35)

(Sonthalia S, et al

Further encouraged by the parallel between COVID-19 and CF in terms of activation of both ENaC and TNF/NFB signaling, we have hypothesized that inflammation in the COVID-19 airway might be due to inhibition of CFTR signaling in normal lung epithelial cells by the SARS-CoV-2 spike protein

C.Alatorre-JimenezM