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#3 Improved Surgical Outcomes Research supports the link between pre-surgery weight loss and improved surgical outcomes

To overcome this bottleneck, Andrew Nguyens team (37) conducted a study using Class I HDAC inhibitor MS-275 (100 g/mouse/day) and found that MS-275 downregulated the expression of the exhaustion marker PD-1, thereby relieving its functional inhibition, while upregulating TIM-3

Their long half-lives mean they can linger for a month after the last dose

Non-caloric supplements (electrolytes, certain nootropics, melatonin) are generally safe, but avoid anything containing amino acids, BCAAs, or sweeteners