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Your healthcare provider will assess your baseline kidney function through blood work and may recommend starting at a lower dose or extending the time between injections

However, the efficacy of these agents remains controversial in conditions such as breast cancer and endometrial cancer (EC), underscoring the importance of elucidating their mechanisms of action in malignancies (12-14)

GLP-1/GIP dual agonist tirzepatide in SYNERGY-NASH trial The SYNERGY-NASH phase 2 trial evaluated tirzepatide, a dual GIP/GLP-1 receptor agonist, in patients with MASH and F2/F3 fibrosis

Baseline estimated renal function was normal (eGFR 90 mL/min/1.73 m2) in 66.2%, mildly impaired (eGFR 60 to 90 mL/min/1.73 m2) in 32.4% and moderately impaired (eGFR 30 to 60 mL/min/1.73 m2) in 1.4% of patients