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Riboflavin (B2) deficiency has been linked, in some ongoing research, to mood disorders and cognitive decline, as well as Parkinsons Disease and depression (1, 9)

This level of reduction is associated with meaningful health benefits, including lower blood pressure and improved cholesterol levels

Safety and side effects: A meta-analysis of multiple studies in COPD patients showed no significant adverse effects at doses ranging from 600 mg to 3g/day.[ref] Studies in healthy adult athletes go up to 20g/day (not recommending this, just including it for safety).[ref] Conversely, in Parkinsons patients, there was a high number of adverse events at 6g/day of NAC