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Inject into healthy skin and avoid problem areas: Do not inject into bruised, sore, hard, red or broken skin

One 2025 real-world cohort study found that patients taking GLP-1/GIP drugs like tirzepatide (Mounjaro, Zepbound) or semaglutide (Ozempic, Wegovy) were about twice as likely to develop alopecia areata compared to those on other weight loss medications like bupropion-naltrexone

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Thus, the vagal sensory neurons that express the receptor and respond to the systemic administration of GLP-1R agonists do not synaptically target the hindbrain GLP-1 neurons