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it is exposed to ROS, primarily in the mitochondria and systems dependent on P450 cytochromes, related principally to lipid synthesis, degradation, the oxidation of fatty acids, and the metabolism of cholesterol and phospholipids for diverse cellular functions, including structural, transport, and others [48,49]
Fluorescence-based measurement of cystine uptake through xCT shows requirement for ROS detoxification in activated lymphocytes
Comparators encompassed all eligible doses of tirzepatide and semaglutide, placebo, and other glucose-lowering drugs directly compared to tirzepatide and semaglutide in at least one trial
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