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The direct interaction between nNOS and sex determining region Y-box 2 in the hippocampus of rats after middle cerebral artery occlusion (MCAO) is significantly improved by co-immunoprecipitation and the promotion of sonic hedgehog transcription as a new feedback compensation mechanism for protecting neurons [108]

This suggests that under T2 stressed conditions, increases in SLC7A11 activity help maintain intracellular redox balance (Figure 3G)