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Sackner MA

New England Journal of Medicine , 375 (19), 1834-1844

In studies on older adults and people losing weight, creatine reduced the amount of lean mass lost during dieting

22 However, the fact that the magnitude and speed of hemoglobin A1c reduction with treatment were identified as risk factors for progression suggests it could be another example of the well-established early worsening phenomenon first observed in type 1 diabetic patients intensively treated with insulin in the Oslo Study, Kroc Collaborative Study and Diabetes Control and Complications Trial