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Understanding when GLP-1 medications begin to work helps set realistic expectations for treatment outcomes

That said, Wegovy is FDA-approved and widely prescribed for weight loss with excellent clinical responses, while retatrutide is still an investigational drug only available through clinical trials and its long-term safety and tolerability are still being studied

Unlike traditional diets that rely on willpower, GLP-1s make you feel full longer by delaying stomach emptying and reducing appetite, leading to natural calorie reduction