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As oral but not intraperitoneal glucose administration stimulates the parasympathetic aspects of the gut-brain axis to centrally mediate hepatic glucose production (168), these findings suggest that INSL-5 may influence glucose homeostasis via direct actions on hepatocytes to influence hepatic gluconeogenesis

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It is used to study GH-axis regulation, receptor pharmacology, and peptide signaling in endocrine and analytical research models