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2008 The cardioprotective action of andrographolide was also completely abolished by buthionine sulfoximine, which acts as a specific gamma-glutamate cysteine ligase (GCL) inhibitor to deplete cellular GSH level

The results of this study suggest that folic acid alleviates oxidative stress and ER stress caused by lead exposure in the kidney by regulating the expression of Nrf2, HO-1, CHOP, and GRP78

Theoretical Concerns From Mechanism While NNMT inhibition is a promising research target, the mechanism raises points that warrant caution in interpretation