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Prior study showed that deficiency of Sentrin/SUMO-specific protease 2 (SENP2) resulted in hyper-SUMOylation of multiple potassium channels and neuronal hyperexcitability, finally triggering spontaneous seizures and sudden death [78, 79], which suggests that sumoylation is vital for epilepsy
Furthermore, colonic mucosal damage in mice is associated with increased susceptibility to colitis, indicating the significant role of iron overload in the pathogenesis of colitis
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