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Moreover, the SURMOUNTMMO (tirzepatide, NCT05556512) will assess the impact of the dual GLP-1/GIP RA in cardiovascular outcomes and all-cause mortality for people with obesity (without diabetes) when the REDEFINE-3 study will assess the impact of cagrisema in people with obesity (with and without T2DM) and established cardiovascular disease

Common side effects reported in trials include: Nausea (the most frequently reported) Vomiting Diarrhoea Constipation Decreased appetite Abdominal discomfort or bloating These effects are largely attributable to the drug's actions on gastric emptying and gut motility

The biological mechanism underlying the rodent findings involves GLP-1 receptor stimulation on thyroid C-cells, which produce calcitonin

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