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Furthermore, combination metformin and 1.8 Gy radiation treatment significantly increased the percentage of early apoptotic HCT116 cells, when compared to irradiated vehicle control ( Figure 3B )

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Aside from dose, timing may also influence carnitine's effects since some data suggests it has a beneficial effect when taken before exercise but this isn't always the case depending on the person's baseline serum carnitine levels, with lower levels requiring longer supplementation periods to elicit exercise performance benefits