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As an antioxidant in animal cells, it exists inside cells filled with water and can protect DNA from oxidation

Zhu J, Li X, Yin J, Hu Y, Gu Y, Pan S

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In the subsequent Examination of Cardiovascular Outcomes with Alogliptin versus Standard of Care (EXAMINE) study of alogliptin there was no statistically significant difference in HF hospitalisation (3.9% vs 3.3% with placebo) [59], and in the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS), the rate of hospitalisation for HF was 3.1% in both sitagliptin- and placebo-treated patients [60]