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showed that changes in SDC-1 mechanical tension generate a tension gradient in SDC-1 under fluid shear force, with SDC-1 interacting differently with the cytoskeleton depending on substrate stiffness, affecting integrin-mediated signaling and focal adhesion formation [49]

In competing with S1P, S1P modulators participate in an intricate cellular machinery of sphingolipids, major components of eukaryotic cell plasma membranes, which play an important role in cellular fate and cell signaling

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