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Signs suggesting adequate treatment include plateau in improvement for two or more weeks, significant resolution of primary concerns, and strong improvement maintained during previous breaks

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Heartburn Rare, but serious side effects may include: Acute pancreatitis (including fatal, hemorrhagic, necrotizing) Acute gallbladder disease Acute kidney injury (typically secondary to dehydration) Severe gastrointestinal disease / delayed gastric emptying Hypoglycemia (especially with insulin or sulfonylureas) Hypersensitivity reactions including anaphylaxis and angioedema Pulmonary aspiration during anesthesia or deep sedation (delayed gastric emptying) Suicidal behavior and ideation (monitor) Diabetic retinopathy complications (in T2D clients with pre-existing retinopathy) Thyroid C-cell tumors (rodent data)