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Under hyperglycemic conditions, RGCs exhibit significant mitochondrial impairment, including cristae dissolution, swelling, vacuolar degeneration, elevated reactive oxygen species (ROS) production, and diminished mitochondrial membrane potential (MMP) [68, 69]

Semaglutide (Wegovy) a licensed GLP-1 receptor agonist approved by the MHRA for weight management in eligible adults, as assessed in NICE technology appraisal TA875

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Medical Consultation and Planning Ahead Even if someone is not participating in a research program, speaking with a medical professional can still be useful