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Trafficking & selectivity profiling: Researchers may evaluate internalization, desensitization, and pathway-selective responses (assay-dependent)

NRF2 activation has been shown to repress the expression of lipogenic genes 64,65,66,67

Not well supported: High-quality, reproducible human trials demonstrating meaningful improvement in tendon/ligament healing time, re-injury rates, or function with these specific compoundsespecially as used in the wild (variable dosing, variable sourcing, variable diagnosis)

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