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Traumatic brain injury and aging: Is a combination of progesterone and vitamin D hormone a simple solution to a complex problem

PMID: 19 ZhouQWangXZhangYWangLChenZ

Three principal challenges warrant emphasis: (1) Translational disconnect: the existing mechanistic insights predominantly derive from rodent models, which exhibit fundamental species-specific disparities in adipose distribution compared to humans

The nasal route facilitates non-invasive administration, avoiding the need for injections or complex delivery systems, which may simplify protocol designs during experimental procedures