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doi: 10.1016/j.molmet.2015.10.005 Summary Keywords metformin, insulin secretion, acetylcholine, autonomic nervous system, MSG-obese rats Citation Franco CCS, Previate C, Trombini AB, Miranda RA, Barella LF, Saavedra LPJ, de Oliveira JC, Prates KV, Tfolo LP, Ribeiro TA, Pavanello A, Malta A, Martins IP, Moreira VM, Matiusso CCI, Francisco FA, Alves VS, de Moraes AMP, de Sant Anna JR, de Castro Prado MAA, Gomes RM, Vieira E and de Freitas Mathias PC (2021) Metformin Improves Autonomic Nervous System Imbalance and Metabolic Dysfunction in Monosodium L-Glutamate-Treated Rats

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GLP-1 receptor agonists provide important cardiometabolic benefits, particularly for weight management, glycemic control, renal protection, and reduction of atherosclerotic cardiovascular risk, although their direct effects in established heart failure remain less certain

By sustaining appropriate DNA methylation, SAMe has a broad range of potential effects on cell repair, inflammatory mediator release, and the pathobiology of ongoing immune-mediated liver injury