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Conversely, the elevated circulating peptides may be attributed to decreased peptide catabolism in the intestinal mucosa and increased uptake of specific peptides

It creates slightly awkward unit numbers for standard doses (62.5 units for 2.5 mg), which makes it harder to measure precisely

A different research project found that genetic variations in the OCT1, PMAT, and SERT transporter proteins were linked to a higher likelihood of gastrointestinal side effects in patients who cannot tolerate metformin (Dujic et al., 2015

The phased approach allows each component to be evaluated individually before adding complexity