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Studies suggest that IGF-1 LR3 might activate key signaling pathways, including the phosphoinositide 3-kinase (PI3K)/Akt and mitogen-activated protein kinase (MAPK) cascades, both of which are central to cellular proliferation and survival

(79(7)):607-610 doi:10.1038/s41430-025-01583-4

But despite its far-reaching potential health benefits, taking a berberine supplement may not be right for everyone