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However, since most of the Pdx1-Cre;Trp53 R172H ;Rb f/f mice develop insulinoma only at the age of over 180 days and those mice die within 2 weeks after presenting with hypoglycemia as previously reported 22 , it is challenging to employ a larger number of the mice to complete our comparative protocol between [ 18 F]FB(ePEG12)12-exendin-4 and [ 68 Ga]DOTATOC PET/CT scans

Practical management considerations include: Dose review: If the heart rate increase is dose-dependent and symptomatic, reducing the dose or slowing the titration schedule where permitted by the trial protocol may help mitigate the effect whilst preserving therapeutic benefit

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