Age-Related Regenerative Decline As we age, regenerative capacity naturally declines
For measurement, organelle isolation often exaggerates apparent ROS production by disrupting matrix buffering and catalase activity, so in situ readouts with genetically encoded, peroxisome-targeted reporters (e.g., HyPer or roGFP-Orp1 fused to a PTS1/SKL signal) are preferred to capture authentic, compartment-confined dynamics (Fransen and Lismont 2024), Fig
B12 deficiency is more common than you might think, especially if you follow a vegetarian or vegan diet, have digestive issues, or are over 50
Farina A, Sekizawa A, De Sanctis P, Purwosunu Y, Okai T, Cha DH, Kang JH, Vicenzi C, Tempesta A, Wibowo N, et al: Gene expression in chorionic villous samples at 11 weeks' gestation from women destined to develop preeclampsia