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Cell lysates were obtained with centrifugation at 14000 rpm for 75 min

Every person responds differently to mounjaro injections

Excess oestrogen is never beneficial, as it contributes to heavy periods, menstrual pain, endometriosis, fibroids, premenstrual syndrome and hormone-dependent cancers such as certain types of breast cancer

Standard clinical dose escalation The FDA-approved Mounjaro (brand tirzepatide) follows this schedule: Weeks 1-4: 2.5 mg once weekly (starting dose, allows GI adaptation) Weeks 5-8: 5 mg once weekly (first therapeutic dose increase) Weeks 9-12: 7.5 mg once weekly (if tolerated and additional effect needed) Weeks 13-16: 10 mg once weekly (continued escalation) Weeks 17-20: 12.5 mg once weekly (approaching maximum) Week 21+: 15 mg once weekly (maximum approved dose) Each dose is maintained for at least four weeks before escalation