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A C18 fatty-diacid chain promotes reversible albumin binding and resistance to DPP-4 degradation, extending the plasma half-life to roughly 7 days and enabling a once-weekly dosing profile in research models

Modulatory role of HMG-CoA reductase inhibitors and ezetimibe on LDL-AGEs-induced ROS generation and RAGE-associated signalling in HEK-293 cells