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Patients should: tell their prescriber if they are planning a pregnancy use appropriate contraception where advised stop treatment and seek medical advice if pregnancy occurs discuss alternative treatment when semaglutide is being used for diabetes avoid using GLP-1 medicines during breastfeeding unless specifically advised by an appropriate clinician The MHRA advises that GLP-1 medicines should not be used during pregnancy, while trying to conceive or during breastfeeding because there is insufficient evidence to establish safety for the baby

In a study published in September, researchers found that patients lost 5.1 percent of their weight on semaglutide (Ozympic) and 2.2 percent on liraglutide (Saxenda), on average

It is critical to emphasise that dedicated cardiovascular outcomes trials (CVOTs) the gold standard for assessing a drug's long-term effect on events such as heart attack and stroke have not yet been completed for retatrutide

Unlike older medications that focus on a single pathway, retatrutide combines multiple effects to provide a more comprehensive approach to weight loss and management