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Vasoconstriction is caused by noradrenaline activated alpha-1 adrenergic receptor released from sympathetic ganglion neurons

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Evidence indicates that a meaningful proportion of weight reduction (~25-40%) may involve lean tissue, including skeletal muscle, particularly in the absence of adequate nutritional intake or strength training

Given the known role of Y1-R in GLP-1R-mediated regulation of insulin secretion, we were surprised to find that Y1-R also stimulated glucose uptake in muscle via a mechanism that was fully independent of insulin stimulation