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( B ) Quantification of glycolysis, glycolytic capacity, and glycolytic reserves in caSMCs pretreated with 100 nM GLP-1(2836) or scrambled control for 20 minutes

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The pharmacological activity of GLP-1 receptor agonists in those populations cannot be assumed to translate identically to adults over 65, who face a different baseline biology

We found that glibenclamide-dependent Rap1 activation was greatly reduced after Barr1 knockdown (Figure 4, D and E), supporting the concept that efficient SU activation of Epac2/Rap1 signaling requires the presence of Barr1