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21 In head-to-head trials, gastrointestinal effects appeared to be greater with liraglutide than exenatide extended-release (DURATION-6) 13 and albiglutide (HARMONY-7) 17 , but liraglutide-treated patients experienced less nausea than those receiving exenatide twice daily (LEAD-6)

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The anti-inflammatory effect of liraglutide is mediated by the GLP-1 receptor signaling pathway To determine whether GLP-1R was the sole target and mediator of the anti-inflammatory effects of liraglutide, we performed a functional competition assay using exendin 939, a GLP-1R competitive antagonist, in both chondrocytes and macrophages (Fig