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Notably, these effects were diminished by either severing the vagus nerve or obstructing GLP-1R pharmacologically

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Designed for convenient daily use, these fast-absorbing oral drops support appetite regulation, satiety, and healthy metabolic function without the need for injections.* GLP-1/GIP therapy works by supporting pathways involved in appetite control, digestion, insulin response, and energy balance

Key dosing points from the study: Dose range: 200500 mcg per session (individual variation based on severity and body weight) Frequency: 23 sessions per week during the active treatment phase Duration: 48 weeks of active treatment Route: Local subcutaneous injection proximal to the affected joint Concurrent therapy: Most patients continued physical therapy alongside BPC-157 treatment The combination of local administration and physical therapy aligns with the hypothesis that BPC-157 accelerates structural repair while functional loading (exercise) guides proper tissue remodeling