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As an alternative approach to improve in vivo stability of the fusion molecule, we then engineered a disulphide bridge into the exendin-4 peptide moiety (Ab#2_DSB#1) as this has been shown to improve in vitro and in vivo stability of both GLP-1 and exendin-4 analogue peptides 36
Slows gastric emptying , contributing to lower post-prandial glucose excursions
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Its crucial to note that individuals with diabetes are not eligible for the Bridge program, as diabetes-related treatments should already be covered by existing health plans
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