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(1988): Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats

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These agents activate AMP-activated protein kinase signaling, leading to suppression of mammalian target of rapamycin complex 1 activity and reduced expression of pro-inflammatory cytokines and adhesion molecules [29]

Study 3: A clinical trial assessed the short/medium-term efficacy of major ozone autohemotherapy on core fibromyalgia symptoms and functional limitations on 25 patients diagnosed with fibromyalgia syndrome (FMS) [37]