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Gene expression modulation: Influences cellular signaling and repair pathways

However, although doubling the dose appears to double the increases in muscle carnosine content during the first 24 weeks of supplementation (46, 50), a higher dose taken for a longer period (6.4 gday 1 for 24 weeks) shows a slowing over time ( Spelnikov and Harris (52) proposed a mathematical model describing the kinetics of carnosine accumulation in human skeletal muscle based on its rate of synthesis and decay

This approach might provide a more informative evaluation of the efficacy of a new therapy by addressing potential confounding factors arising from imbalanced baseline features (24)