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The indirectly acting sympathomimetic drugs, like amphetamines, have common properties such as causing both increased catecholamine release and the inhibition of catecholamine re-uptake (primarily dopamine) at nerve endings in the Central Nervous System (CNS)

SURPASS-2 showed tirzepatide was superior to semaglutide 1mg for both A1C reduction (2.09% vs 1.86%) and weight loss (12.4% vs 6.2%) at the 15mg dose, establishing the clinical relevance of dual-agonism over selective GLP-1 agonism

Our approach to B12 injections reflects this philosophy

Remember that vitamin B12 must attach to a protein called intrinsic factor, which is secreted in the stomach to be absorbed