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The American College of Physicians and American Diabetes Association emphasize that treatment decisions should be individualized based on patient preferences, comorbidities, and clinical circumstances, with shared decision-making between patients and healthcare providers

It involved six aspects, which were the bias generated by the randomization process, the bias generated by the randomization sequence, whether the blind method was implemented between participants and researchers, the bias of result evaluation, the bias caused by incomplete result data, and the bias of selective reporting results

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