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AMPK activation = increased glucose uptake and fat oxidation Downregulates anabolic processes that consume ATP Promotes mitochondrial biogenesis and cellular resilience MOTSc functions as a mitochondrial-encoded hormone that enhances metabolic flexibility and insulin sensitivity. Lee et al., Cell Metabolism Natural Expression and Peptide Supplementation Your body naturally produces MOTSc, particularly during fasting or exercise

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Together, these findings suggested high public interest in GLP-1 RA and identified potential priorities for the clinical and policy communities, including monitoring side effects, addressing access barriers, and acknowledging both the physical and psychological benefits of GLP-1 RAs