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The extent of skin lightening depends on various biological factors

In contrast to patients with other nuclear encoded Complex I defects who typically have a severe clinical presentation and associated early death, it has been suggested that pathogenic variants in the FOXRED1 gene result in partial loss of function and are probably hypomorphic due to the longer survival of patients [61]

DUAL TARGETING OF GLUTATHIONE REDUCTASE TO MITOCHONDRIA AND CHLOROPLASTS 2005 Glutathione/thioredoxin systems modulate mitochondrial H2O2 emission: An experimental-computational study 2012