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2.2.1 B cells B cell maturation and differentiation into plasma cells require robust phospholipid synthesis and remodeling to sustain multiple rounds of proliferation, clonal expansion, and antibody production (103)

Market & regulatory implications If human translation succeeds, FOXO4-DRI or analogues may form the backbone of senotherapy clinics alongside peptides, hormones and regenerative medicine

The increased sensitivity of TRIP13 knockout cells may reflect a loss of protective mechanisms that are normally conferred by TRIP13, such as its role in mitotic regulation [41] or maintenance of genome stability during stress conditions [47]

Mechanistic studies to better understand the molecular targets and pathways involved in peptide action could help identify potential adverse effects and inform safer clinical use