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SLH reports support by grants from the National Institutes of Health and Office of Dietary Supplements (P20HL113452 and R01HL103866)

Although a dual agonist capable of activating both GLP1R and GIPR , Tirzepatide preferentially activates GIPR more, over GLP1R

The development of these agents underscores the continuous improvement of the pharmacokinetic and pharmacodynamic profiles of these peptide agents [ Table 1 ], expanding their applications beyond T2DM and obesity to encompass cardiovascular disease event reduction [ Table 2 ]

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