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Inflammatory cytokines in diabetic kidney disease: pathophysiologic and therapeutic implications

Decreasing extracellular fluid volume, they might decrease ARR like thiazide diuretics, leading to false-negative screening for PA in patients with T2DM ( Effects of GLP-1 Receptor Agonists on RAAS GLP-1 receptor agonists (GLP1-RA) are a relatively novel class of anti-diabetic drugs that improve glycemic control by potentiating the physiological effect of the gut hormone GLP-1 ( Since cardiovascular complications of diabetes ( Both acute GLP-1 infusion ( GLP-1 may also inhibit ANG II action at post-receptor level

B12 may also optimize metabolic functioning, making it an adjunct in weight management goals

Neurotrophic agents such as nerve growth factor and brain-derived neurotrophic factor have received research attention concerning their potential to treat AD but have not progressed to clinical trials due to their reasonably large size, inability to penetrate the blood-brain barrier (BBB), and the high cost of synthesis