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Evidence source : NEJM (2023 Phase 2), Novo Nordisk trials (NCT04982530)

Nature 454:232235 Jagadeeswaran R, Lenny H, Vazquez B et al (2017) The abnormal Presence of mitochondria in circulating red blood cells cause an increased oxygen consumption rate, ROS generation and hemolysis in patients with sickle cell disease

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Understanding these differences prevents both premature disposal of good product and use of degraded material