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The TXN system suppresses ferroptosis through multiple mechanisms: by supplying reducing equivalents to PRDXs, facilitating cystine-to-cysteine reduction to support GSH synthesis, and acting as an independent ferroptosis suppressor (Fig

150 An uncontrolled trial in 60 men with infertility, despite having normal sperm counts, found 5 grams of ashwagandha root powder daily for 90 days reduced levels of markers of psychological stress, decreased semen oxidative stress, and resulted in a 14% pregnancy rate

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