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In both studies, tirzepatide reportedly achieved all primary and key secondary endpoints, resulting in a mean reduction of up to 62.8% on the Additionally, the study found that of participants treated with tirzepatide at the highest dose, 43% in Study 1 and 51.5% in Study 2 met the criteria for obstructive sleep apnea disease resolution. Obstructive sleep apnea is a comorbidity of obesity, meaning it is most commonly seen in people with overweight or obesity

found that neuronal death triggered a glial reaction, in which the CD95/CD95L system is involved and acts through the non-apoptotic pathway in the cerebellum of Lurcher mice [104]

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In: Peterson ME, Talcott PA, eds