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Key Takeaways Orforglipron and semaglutide both mimic GLP-1 but differ in structure
The tradeoff is that more receptors also means more side effects, especially nausea and (for retatrutide) unusual skin sensations
The proposed mechanisms include upregulation of beta-3 adrenergic receptors in adipose tissue, activation of the cAMP-PKA lipolytic cascade through enhanced catecholamine sensitivity, direct or indirect inhibition of acetyl-CoA carboxylase (ACC) reducing de novo lipogenesis by approximately 43-57% in vitro, and activation of hormone-sensitive lipase (HSL) with increased glycerol release
doi: 10.1161/ATVBAHA.122.318834 6
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